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While the Small Ruminants' Plague does not infect humans, the U.N. agency said it could have a shocking economic and social impact across the region.
"Sheep and goats are dangerous to food and income security for pastoral communities. The presence of the disease openly affects a family's wealth," the FAO's chief veterinary officer, Juan Lubroth, said in a statement.
The disease broke out in Tanzania early on this year, the FAO said. It is easily spread as animals make contact in pastures and in markets, according to Adama Diallo, who led a recent FAO-sponsored emergency mission to Tanzania.
Diallo suggest an emergency vaccination program around outbreak sites and herding routes, particularly along borders with Malawi, Mozambique and Zambia, and those authorities not allow herders to move their flocks.
The disease has formerly infected western, eastern and central Africa. It is also found in the Mideast and parts of central Asia, the FAO said.